Latent Space: The AI Engineer Podcast
npub1ntf7j0dy6uep8u0dxl0je8jatxqj59f4srv8gt9vcujaxxga6xaqfzhv2c@drss.io
The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space Sponsorship and business inquiries: business@latent.space [www.latent.space](https://www.latent.space?utm_medium=podcast)
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🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
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11 Aug 2026
This January, four big AI × Pharma tools deals were announced at the huge JPM Pharma conference that takes over San Francisco every year.
The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
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3 Aug 2026
We first [covered Baseten](https://www.youtube.com/watch?v=KjH7Gl0_pq0) last year when DeepSeek mania was at peak hype. Now they have raised a [monster $13B
Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
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28 Jul 2026
There are roughly 100x more people who use code than who can write code. As code that “just works” becomes easier to generate, this group may be the biggest prize of all — if you can get the
Inside the Model Factory — Eiso Kant, Poolside AI
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23 Jul 2026
In recent months, the open vs closed, and [US vs China](https://www.latent.space/p/ainews-kimi-k3-28t-a50b-the-largest) discussions on model ownership and sovereign/local AI have heated up to a fever
Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
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21 Jul 2026
Bet on information If *test loss flatlines* after 1.5B parameters while *training loss continues to drop* as you scale, that tells you that your model is *limited by the amount of information* in
🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
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16 Jul 2026
Imagine a dark warehouse. Racks and racks of devices with wires, tubes, and electronics sticking out. **The next AI data center? No.** This is [Lila Sciences](https://www.lila.ai/)‘ dream for the
Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
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8 Jul 2026
We’ve been running a bit of an Agent Cloud series surveying all the top inference/compute/cloud providers, from [Databricks](https://www.latent.space/p/databricks) to
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
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1 Jul 2026
This episode has a fun personal twist: There’s a counterfactual world where I was employee #1 at [Genesis Molecular AI](https://www.genesis.ml/), the company behind today’s episode. A certain
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
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24 Jun 2026
*We’re excited to have Databricks join us at* [*AIEWF*](https://www.ai.engineer/worldsfair/2026)*, among* [*hundreds of the top companies*](https://www.ai.engineer/worldsfair/2026#expo) *in the AI
Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
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22 Jun 2026
[AI Engineer World’s Fair](http://ai.engineer/wf) regular bird tix will sell out ~today! [Join us next week](https://www.latent.space/p/exclusive-250-off-ai-engineer-tix) ahead of the Late Bird
The Professor of Outputmaxxing — Anjney Midha, AMP
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18 Jun 2026
*Last 4 days before regular tickets sell out at* [*AI Engineer World’s Fair*](https://www.ai.engineer/worldsfair/2026) *- this is the single biggest gathering of AI Engineers, Founders, Leaders,
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
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17 Jun 2026
On the Science pod, we’ve been covering a lot of the ground on how AI is revolutionizing STEM, but one of our favorite off the record topics since our launch is [which field is
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
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4 Jun 2026
*The new* [*AIEWF website*](https://ai.engineer/wf) *is live! Get your tickets booked ASAP as they -will- sell out. Take the* [*AI Engineering
🔬Scaling Past Informal AI - Carina Hong, Axiom Math
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3 Jun 2026
In 2025, seven-month-old startup [Axiom solved all 12 of the problems Putnam exam](https://axiommath.ai/territory/from-seeing-why-to-checking-everything) (scoring 8/12 in the time limit) a
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
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3 Jun 2026
We’ve informally heard that Satya is a listener to LS for a couple years now, but it was still absolutely surreal to meet him and do a live pod at Build, together with our friends at **No Priors**,
GitHub's plan for Agents — Kyle Daigle, GitHub
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2 Jun 2026
*I’m excited to work with Microsoft once again as the presenting sponsors of the* [*AI Engineer World’s Fair*](https://www.ai.engineer/worldsfair/2026)*!* *We’ll streaming live from* [*MS
Why Video Agent models are next — Ethan He, xAI Grok Imagine
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1 Jun 2026
*We’re announcing* [*AIEWF*](https://ai.engineer/wf) *speakers this week! Take the* [*AI Engineering Survey*](https://notion.qualtrics.com/jfe/form/SV_bP07tSVMXH7ePCS)*!* Today’s guest Ethan
The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
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28 May 2026
*The new* [*AIEWF website*](https://ai.engineer/wf) *is live!* [*CFPs*](https://ai.engineer/cfp) *close in 2 days and we will run our first New Engineer Orientation this weekend, get your tickets
🔬ESMFold2: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
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27 May 2026
*Editor’s note: In our* [*first BioHub pod with Priscilla and Mark*](http://latent.space/p/biohub) *they discussed their* [*acquisition of
🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
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27 May 2026
*Editor’s note: In our* [*first BioHub pod with Priscilla and Mark*](http://latent.space/p/biohub) *they discussed their* [*acquisition of
Giving Agents Computers — Ivan Burazin, Daytona
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21 May 2026
*Take the* [*2026 AI Engineering Survey*](https://notion.qualtrics.com/jfe/form/SV_bP07tSVMXH7ePCS) *and get >$2k in credits and* [*AIE WF tickets*](https://ai.engineer/wf)*!* On the product
Railway: The Agent-Native Cloud — Jake Cooper
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20 May 2026
*Take the* [*2026 AI Engineering Survey*](https://notion.qualtrics.com/jfe/form/SV_bP07tSVMXH7ePCS) *and get >$2k in credits and* [*AIE WF tickets*](https://ai.engineer/wf)*!* *This was recorded
The Next War Is Already Here. The West Isn't Ready. — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
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18 May 2026
The future of war has been evolving before our eyes in Ukraine, yet the west still plans to fight the last war. In this special episode, guest host [**Noah
The Next War Is Already Here. The West Isn't Ready. — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
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18 May 2026
The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
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18 May 2026
The future of war has been evolving before our eyes in Ukraine, yet the west still plans to fight the last war. In this special episode, guest host [**Noah
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
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14 May 2026
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
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14 May 2026
*Special discounts up for* [*AIE Melbourne*](http://ai.engineer/melbourne) *(*[*LS discount*](http://ai.engineer/mb)*) and* [*AIE World’s Fair*](http://ai.engineer/wf) *(group discounts up to 25%
🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
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5 May 2026
Some people are going crazy over GPT 5.5. *Some* people. This is the story of the [Jagged](https://www.notion.so/Tanishq-https-x-com-iScienceLuvr-2c312774e7a88187a391e2a67b42cd56?pvs=21)
Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
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27 Apr 2026
From building [**Applied Intuition**](https://www.appliedintuition.com/) from **YC-era** autonomy tooling into a **$15B physical AI company**, [**Qasar Younis**](https://x.com/qasar) and [**Peter
AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
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23 Apr 2026
Today, we check in a year after the [first](https://www.latent.space/p/unsupervised-learning) [**Unsupervised Learning x Latent Space Crossover
Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
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22 Apr 2026
*Early bird discounts for* [*the San Francisco World’s Fair*](https://www.ai.engineer/wf)*, the biggest AIE gathering of the year, end today - prices will go up by ~$500 tonight so do please lock
🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
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20 Apr 2026
Today, we explain this piece of “clickbait” from our guest! **TL;DR: 95% of cancer treatments fail to** [**pass clinical trials**](https://www.nature.com/articles/s41467-025-64552-2)**, but it
Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
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15 Apr 2026
*For all those who missed out on London, see you in* [*Miami*](https://www.ai.engineer/miami) *next week!* Notion, the [knowledge work
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
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7 Apr 2026
*We’re proud to release this ahead of* [*Ryan’s keynote at AIE Europe*](https://www.youtube.com/watch?v=O_IMsEg91g8)*. Hit the bell, get notified when it is live! Attendees: come prepped for*
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
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3 Apr 2026
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
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3 Apr 2026
Fresh off [raising a monster $15B](https://a16z.com/why-did-we-raise-15b/), [Marc Andreessen](http://x.com/pmarca) has lived through multiple computing platform shifts firsthand, from Mosaic and
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
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2 Apr 2026
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
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2 Apr 2026
We’ve been on a bit of a mini World Models series over the last quarter: from introducing the topic with [Yi
